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ranolazine demonstrated a trend toward increase in invasively measured cardiac output

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In SYNergy between percutaneous coronary intervention with TAXus and cardiac surgery (SYNTAX), 1800 patients with three-vessel or left main coronary artery disease were randomized to undergo CABG or PCI.

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Martinez explained the indication for the therapy to the patient and his wife by educating them about ST elevations and the need to treat symptoms quickly in order to provide blood supply to the heart muscle.

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One aspect of the invention provides for treating a patient suffering from coronary microvascular disease comprising selecting a patient suffering from, or at risk of suffering from, coronary microvascular disease and administering to that patient an effective amount of ranolazine.

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